| http://purl.uniprot.org/citations/12177062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12177062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12177062 | http://www.w3.org/2000/01/rdf-schema#comment | "The Cbl family of ubiquitin ligases in mammals contains three members, Cbl, Cbl-b, and Cbl-3, that are involved in down-regulation of receptor tyrosine kinases (RTKs) by mediating receptor ubiquitination and degradation. More recently, a novel pathway has been identified whereby Cbl promotes internalization of EGF receptor via a CIN85/endophilin pathway that is functionally separable from the ubiquitin ligase activity of Cbl (1). Here we show that Cbl-b, but not Cbl-3, utilize the same mechanism to down-regulate multiple RTKs. CIN85 was shown to bind to the minimal binding domain identified in the carboxyl terminus of Cbl-b. Ligand-induced phosphorylation of Cbl-b further increased their interactions and led to a rapid and sustained recruitment of CIN85 in the complex with EGF or PDGF receptors. Inhibition of binding between CIN85 and Cbl-b was sufficient to impair Cbl-b-mediated internalization of EGF receptors, while being dispensable for Cbl-b-directed polyubiquitination of EGF receptors. Moreover, CIN85 and Cbl/Cbl-b were constitutively associated with activated PDGF, EGF, or c-Kit receptors in several tumor cell lines. Our data reveal a common pathway utilized by Cbl and Cbl-b that may have an important and redundant function in negative regulation of ligand-activated as well as oncogenically activated RTKs in vivo."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205535200"xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205535200"xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Dikic I."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Dikic I."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Soubeyran P."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Soubeyran P."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Szymkiewicz I."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Szymkiewicz I."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Dinarina A."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Dinarina A."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Kowanetz K."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Kowanetz K."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Lipkowitz S."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/author | "Lipkowitz S."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/pages | "39666-39672"xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/pages | "39666-39672"xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/title | "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases."xsd:string |
| http://purl.uniprot.org/citations/12177062 | http://purl.uniprot.org/core/title | "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases."xsd:string |