| http://purl.uniprot.org/citations/12189203 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12189203 | http://www.w3.org/2000/01/rdf-schema#comment | "The physiological meaning of the coexpression of adenosine A2A receptors and group I metabotropic glutamate receptors in gamma-aminobutyric acid (GABA)ergic striatal neurons is intriguing. Here we provide in vitro and in vivo evidence for a synergism between adenosine and glutamate based on subtype 5 metabotropic glutamate (mGluR5) and adenosine A2A (A2AR) receptor/receptor interactions. Colocalization of A2AR and mGluR5 at the membrane level was demonstrated in nonpermeabilized human embryonic kidney (HEK)-293 cells transiently cotransfected with both receptors by confocal laser microscopy. Complexes containing A2AR and mGluR5 were demonstrated by Western blotting of immunoprecipitates of either Flag-A2AR or hemagglutinin-mGluR5 in membrane preparations from cotransfected HEK-293 cells and of native A2AR and mGluR5 in rat striatal membrane preparations. In cotransfected HEK-293 cells a synergistic effect on extracellular signal-regulated kinase 1/2 phosphorylation and c-fos expression was demonstrated upon A2AR/mGluR5 costimulation. No synergistic effect was observed at the second messenger level (cAMP accumulation and intracellular calcium mobilization). Accordingly, a synergistic effect on c-fos expression in striatal sections and on counteracting phencyclidine-induced motor activation was also demonstrated after the central coadministration of A2AR and mGluR5 agonists to rats with intact dopaminergic innervation. The results suggest that a functional mGluR5/A2AR interaction is required to overcome the well-known strong tonic inhibitory effect of dopamine on striatal adenosine A2AR function."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.172393799"xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Lluis C."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Fuxe K."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Burgueno J."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Ciruela F."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Franco R."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Casado V."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Ferre S."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Gutierrez M.A."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Goldberg S.R."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Hope B.T."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Karcz-Kubicha M."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/author | "Popoli P."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/pages | "11940-11945"xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/title | "Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function."xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/12189203 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12189203 |
| http://purl.uniprot.org/citations/12189203 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12189203 |
| http://purl.uniprot.org/uniprot/P30543#attribution-9A2CA79D6D05D3D684CF5859ADA79677 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12189203 |
| http://purl.uniprot.org/uniprot/P30543#attribution-E39534E14BE45A0ED1D2BE80461C4481 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12189203 |
| http://purl.uniprot.org/uniprot/P31424#attribution-9A2CA79D6D05D3D684CF5859ADA79677 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12189203 |