| http://purl.uniprot.org/citations/12208882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12208882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12208882 | http://www.w3.org/2000/01/rdf-schema#comment | "The recently described junctional adhesion molecules (JAMs) in man and mice are involved in homotypic and heterotypic intercellular interactions. Here, a third member of this family, human JAM-3, was identified and described as a novel counterreceptor on platelets for the leukocyte beta2-integrin Mac-1 (alphaMbeta2, CD11b/CD18). With the help of two monoclonal antibodies, Gi11 and Gi13, against a 43-kD surface glycoprotein on human platelets, a full-length cDNA encoding JAM-3 was identified. JAM-3 is a type I transmembrane glycoprotein containing two Ig-like domains. Although JAM-3 did not undergo homophilic interactions, myelo-monocytic cells adhered to immobilized JAM-3 or to JAM-3-transfected cells. This heterophilic interaction was specifically attributed to a direct interaction of JAM-3 with the beta2-integrin Mac-1 and to a lower extent with p150.95 (alphaXbeta2, CD11c/CD18) but not with LFA-1 (alphaLbeta2, CD11a/CD18) or with beta1-integrins. These results were corroborated by analysis of K562 erythroleukemic cells transfected with different heterodimeric beta2-integrins and by using purified proteins. Moreover, purified JAM-3 or antibodies against JAM-3 blocked the platelet-neutrophil interaction, indicating that platelet JAM-3 serves as a counterreceptor for Mac-1 mediating leukocyte-platelet interactions. JAM-3 thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies such as in atherothrombosis."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20020267"xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20020267"xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Linder M."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Linder M."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Preissner K.T."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Preissner K.T."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Chavakis T."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Chavakis T."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Ruf A."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Ruf A."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Santoso S."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Santoso S."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Kroll H."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Kroll H."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Sachs U.J.H."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/author | "Sachs U.J.H."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/pages | "679-691"xsd:string |
| http://purl.uniprot.org/citations/12208882 | http://purl.uniprot.org/core/pages | "679-691"xsd:string |