| http://purl.uniprot.org/citations/12218089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12218089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12218089 | http://www.w3.org/2000/01/rdf-schema#comment | "In resting T cells, Csk is constitutively localized in lipid rafts by virtue of interaction with a phosphorylated adaptor protein, Csk-binding protein (Cbp)/phosphoprotein associated with glycolipid-enriched microdomains, and sets an activation threshold in TCR signaling. In this study, we examined a kinase responsible for Cbp phosphorylation in T cell membrane rafts. By analyzing T cells from Fyn-/-mice, we clearly demonstrated that Fyn, but not Lck, has its kinase activity in membrane rafts, and plays a critical role in Cbp phosphorylation, Cbp-Csk interaction, and Csk kinase activity. Naive CD44(low)CD62 ligand(high) T cells were substantially reduced in Fyn-/-mice, presumably due to the inhibition of Cbp phosphorylation. Thus, Fyn mediates Cbp-Csk interaction and recruits Csk to rafts by phosphorylating Cbp. Csk recruited to rafts would then be activated and inhibit the kinase activity of Lck to keep resting T cells in a quiescent state. Our results elucidate a negative regulatory role for Fyn in proximal TCR signaling in lipid rafts."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.6.2813"xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.6.2813"xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Kato A."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Kato A."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Yagi T."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Yagi T."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Yasuda K."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Yasuda K."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Hamaoka T."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Hamaoka T."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Kosugi A."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Kosugi A."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Shima T."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Shima T."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Minaki Y."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Minaki Y."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Nagafuku M."xsd:string |
| http://purl.uniprot.org/citations/12218089 | http://purl.uniprot.org/core/author | "Nagafuku M."xsd:string |