| http://purl.uniprot.org/citations/12242332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12242332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12242332 | http://www.w3.org/2000/01/rdf-schema#comment | "This paper describes insig-2, a second protein of the endoplasmic reticulum that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to SCAP (SREBP cleavage-activating protein) in a sterol-regulated fashion, thus preventing it from escorting SREBPs to the Golgi. By blocking this movement, insig-2, like the previously described insig-1, prevents the proteolytic processing of SREBPs by Golgi enzymes, thereby blocking cholesterol synthesis. The sequences of human insig-1 and -2 are 59% identical. Both proteins are predicted to contain six transmembrane helices. The proteins differ functionally in two respects: (i) production of insig-1, but not insig-2, in cultured mammalian cells requires nuclear SREBPs; and (ii) at high levels of expression, insig-1, but not insig-2, can block SCAP movement in the absence of exogenous sterols. The combined actions of insig-1 and -2 permit feedback regulation of cholesterol synthesis over a wide range of sterol concentrations."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.162488899"xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.162488899"xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/author | "Brown M.S."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/author | "Brown M.S."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/author | "Goldstein J.L."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/author | "Goldstein J.L."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/author | "Yabe D."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/author | "Yabe D."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/pages | "12753-12758"xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/pages | "12753-12758"xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/title | "Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/title | "Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins."xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/12242332 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12242332 |
| http://purl.uniprot.org/citations/12242332 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12242332 |
| http://purl.uniprot.org/citations/12242332 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12242332 |
| http://purl.uniprot.org/citations/12242332 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12242332 |