| http://purl.uniprot.org/citations/12244174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12244174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12244174 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocyte growth factor/scatter factor (HGF) and its receptor tyrosine kinase Met are key regulators of epithelial motility and morphogenesis. Recent studies indicate that the HGF/Met pathway also plays a role in B cell differentiation, whereas uncontrolled Met signaling may lead to B cell neoplasia. These observations prompted us to explore HGF/Met signaling in B cells. In this study, we demonstrate that HGF induces strong tyrosine phosphorylation of the proto-oncogene product c-Cbl in B cells and increases Cbl association with the Src family tyrosine kinases Fyn and Lyn, as well as with phosphatidylinositol-3 kinase and CrkL. In addition, we demonstrate that c-Cbl mediates HGF-induced ubiquitination of Met. This requires the juxtamembrane tyrosine Y1001 (Y2) of Met, but not the multifunctional docking site (Y14/15) or any additional C-terminal tyrosine residues (Y13-16). In contrast to wild-type c-Cbl, the transforming mutants v-Cbl and 70Z/3 Cbl, which lack the ubiquitin ligase RING finger domain, suppress Met ubiquitination. Our findings identify c-Cbl as a negative regulator of HGF/Met signaling in B cells, mediating ubiquitination and, consequently, proteosomal degradation of Met, and suggest a role for Cbl in Met-mediated tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.7.3793"xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.7.3793"xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Borst J."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Borst J."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Pals S.T."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Pals S.T."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Spaargaren M."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Spaargaren M."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Beuling E.A."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Beuling E.A."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Taher T.E."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Taher T.E."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Tjin E.P."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/author | "Tjin E.P."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/pages | "3793-3800"xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/pages | "3793-3800"xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/title | "c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/12244174 | http://purl.uniprot.org/core/title | "c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination."xsd:string |