| http://purl.uniprot.org/citations/12361598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12361598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12361598 | http://www.w3.org/2000/01/rdf-schema#comment | "Centrosome duplication and separation are linked inextricably to certain cell cycle events, in particular activation of cyclin-dependent kinases (CDKs). However, relatively few CDK targets driving these events have been uncovered. Here, we have performed a screen for CDK substrates and have isolated a target, CP110, which is phosphorylated by CDKs in vitro and in vivo. Human CP110 localizes to centrosomes. Its expression is strongly induced at the G1-to-S phase transition, coincident with the initiation of centrosome duplication. RNAi-mediated depletion of CP110 indicates that this protein plays an essential role in centrosome duplication. Long-term disruption of CP110 phosphorylation leads to unscheduled centrosome separation and overt polyploidy. Our data suggest that CP110 is a physiological centrosomal CDK target that promotes centrosome duplication, and its deregulation may contribute to genomic instability."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00258-7"xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00258-7"xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "Dynlacht B.D."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "Dynlacht B.D."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "Indjeian V.B."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "Indjeian V.B."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "McManus M."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/author | "McManus M."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/pages | "339-350"xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/pages | "339-350"xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/title | "CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/title | "CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells."xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/12361598 | http://purl.uniprot.org/core/volume | "3"xsd:string |