| http://purl.uniprot.org/citations/12370298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12370298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12370298 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor (TNF) is a cytokine that mediates many pathophysiologial processes, including angiogenesis. However, the molecular signaling involved in TNF-induced angiogenesis has not been determined. In this study, we examined the role of Etk/Bmx, an endothelial/epithelial tyrosine kinase involved in cell adhesion, migration, and survival in TNF-induced angiogenesis. We show that TNF activates Etk specifically through TNF receptor type 2 (TNFR2) as demonstrated by studies using a specific agonist to TNFR2 and TNFR2-deficient cells. Etk forms a preexisting complex with TNFR2 in a ligand-independent manner, and the association is through multiple domains (pleckstrin homology domain, TEC homology domain, and SH2 domain) of Etk and the C-terminal domain of TNFR2. The C-terminal 16-amino-acid residues of TNFR2 are critical for Etk association and activation, and this Etk-binding and activating motif in TNFR2 is not overlapped with the TNFR-associated factor type 2 (TRAF2)-binding sequence. Thus, TRAF2 is not involved in TNF-induced Etk activation, suggesting a novel mechanism for Etk activation by cytokine receptors. Moreover, a constitutively active form of Etk enhanced, whereas a dominant-negative Etk blocked, TNF-induced endothelial cell migration and tube formation. While most TNF actions have been attributed to TNFR1, our studies demonstrate that Etk is a TNFR2-specific kinase involved in TNF-induced angiogenic events."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.21.7512-7523.2002"xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.21.7512-7523.2002"xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "Pan S."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "Pan S."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "Yin G."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "Yin G."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "Min W."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "Min W."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "An P."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/author | "An P."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/pages | "7512-7523"xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/pages | "7512-7523"xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/title | "Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/12370298 | http://purl.uniprot.org/core/title | "Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis."xsd:string |