| http://purl.uniprot.org/citations/12370310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12370310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12370310 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify novel genes that play critical roles in mediating bone morphogenetic protein (BMP) signal pathways, we performed a yeast two-hybrid screen using Smad1 as bait. A novel mouse Krüppel-type zinc finger protein, mZnf8, was isolated. Interactions between mZnf8 and Smad proteins were further analyzed with various in vitro and in vivo approaches, including mammalian two-hybrid, in vitro glutathione S-transferase pulldown, and copurification assays. Results from functional analysis indicate that mZnf8 is a nuclear transcriptional repressor. Overexpression of mZnf8 represses activity of BMP and transforming growth factor beta (TGF-beta) reporters. Silencing the expression of endogenous mZnf8 with an RNA interference approach caused a significant increase in the expression of one BMP reporter. These results suggest that mZnf8 negatively regulates the TGF-beta/BMP signaling pathway in vivo. Transcription of mZnf8 is ubiquitous in mouse embryos, but high levels are specifically observed in adult mouse testes, with the same cell- and stage-specific transcription pattern as Smad1. Our data support the hypothesis that mZnf8 plays critical roles in mediating BMP signaling during spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.21.7633-7644.2002"xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.21.7633-7644.2002"xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/author | "Hogan B.L.M."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/author | "Hogan B.L.M."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/author | "Jiao K."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/author | "Jiao K."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/pages | "7633-7644"xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/pages | "7633-7644"xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/title | "Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/title | "Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1."xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12370310 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12370310 |
| http://purl.uniprot.org/citations/12370310 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12370310 |
| http://purl.uniprot.org/citations/12370310 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12370310 |
| http://purl.uniprot.org/citations/12370310 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12370310 |