| http://purl.uniprot.org/citations/12381733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12381733 | http://www.w3.org/2000/01/rdf-schema#comment | "A new long form of the c-Maf transcription factor (Lc-Maf) was identified and shown to interact specifically with SOX9 in a yeast two-hybrid cDNA library screening. Lc-Maf encodes an extra 10 amino acids at the carboxyl terminus of c-Maf and contains a different 3'-untranslated region compared with c-Maf. The interaction between SOX9 and Lc-Maf was further confirmed by co-immunoprecipitation and glutathione S-transferase pull-down assays, which mapped the interacting domain of SOX9 to the high mobility group box DNA binding domain and that of Lc-Maf to the basic leucine zipper motif. In situ hybridizations showed that Lc-Maf RNA was coexpressed with Sox9 and Col2a1 RNA in areas of precartilaginous mesenchymal condensations during mouse embryo development. A DNA binding site of Lc-Maf was identified at the 5'-end of a 48-bp Col2a1 enhancer element near the high mobility group binding site of SOX9. Lc-Maf and SOX9 synergistically activated a luciferase reporter plasmid containing a Col2a1 enhancer and increased the transcription of the endogenous Col2a1 gene. In summary, Lc-Maf is the first transcription factor shown to interact with Sox9, to be coexpressed with Sox9 during an early step of chondrogenesis and to cooperate with Sox9 in activating a downstream target gene of Sox9."xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m206544200"xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/author | "Lu N."xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/author | "Eberspaecher H."xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/author | "De Crombrugghe B."xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/pages | "50668-50675"xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/title | "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene."xsd:string |
| http://purl.uniprot.org/citations/12381733 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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