| http://purl.uniprot.org/citations/12384582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12384582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12384582 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous work has identified a group of genes whose products play important roles in two seemingly unrelated processes: cell cycle progression and splicing. The products of these genes show a network of physical and genetic interactions suggestive of the existence of a protein complex, the cell cycle and splicing complex (CSC). Here we analyze the genetic interactions between ISY1, SYF2 and NTC20, three non-essential components of the CSC. We show that mutations in ISY1 cause lethality in the absence of Ntc20p, and that the double mutant isy1Delta syf2Delta shows a temperature-dependent cell cycle arrest. This arrest is due to lower levels of alpha-tubulin, a protein encoded by TUB1 and TUB3, two intron-containing genes. We show that the low levels of alpha-tubulin in isy1Delta syf2Delta trigger activation of the spindle checkpoint, causing cell cycle arrest. Thus, our results have uncovered an unexpected role for pre-mRNA splicing in the maintenance of the fidelity of chromosome transmission during cell division."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkf563"xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkf563"xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/author | "Kupiec M."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/author | "Kupiec M."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/author | "Dahan O."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/author | "Dahan O."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/pages | "4361-4370"xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/pages | "4361-4370"xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/title | "Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/title | "Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint."xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/12384582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12384582 |
| http://purl.uniprot.org/citations/12384582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12384582 |
| http://purl.uniprot.org/citations/12384582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12384582 |
| http://purl.uniprot.org/citations/12384582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12384582 |
| http://purl.uniprot.org/uniprot/P21374 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12384582 |
| http://purl.uniprot.org/uniprot/P53277 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12384582 |