| http://purl.uniprot.org/citations/12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12393874 | http://www.w3.org/2000/01/rdf-schema#comment | "The transforming growth factor beta (TGF-beta) receptor, ALK-1, is expressed specifically on endothelial cells and is essential for angiogenesis, as demonstrated by its targeted deletion in mice and its mutation in the human disease hereditary hemorrhagic telangiectasia. Although ALK-1 and another endothelial-specific TGF-beta receptor, endoglin, both bind TGF-beta with identical isoform specificity and form a complex together, neither has been shown to signal in response to TGF-beta, and the mechanism by which these receptors signal in endothelial cells remains unknown. Here we report the identification of the nuclear receptor liver X receptor beta (LXRbeta) as a modulator/mediator of ALK-1 signaling. The cytoplasmic domain of ALK-1 specifically binds to LXRbeta in vitro and in vivo. Expression of activated ALK-1 results in translocation of LXRbeta from the nuclear compartment to the cytoplasmic compartment. The interaction of activated ALK-1 with LXRbeta in the cytoplasmic compartment results in the specific phosphorylation of LXRbeta by ALK-1, primarily on serine residues. LXRbeta subsequently modulates signaling by ALK-1 and the closely related TGF-beta receptor, ALK-2, as demonstrated by specific and potent inhibition of ALK-1- and ALK-2-mediated transcriptional responses, establishing LXRbeta as a potential modulator/mediator of ALK-1/ALK-2 signaling."xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210376200"xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/author | "Mo J."xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/author | "Blobe G.C."xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/author | "Fang S.J."xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/pages | "50788-50794"xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/title | "Regulation of ALK-1 signaling by the nuclear receptor LXRbeta."xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12393874 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12393874 |
| http://purl.uniprot.org/citations/12393874 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12393874 |
| http://purl.uniprot.org/uniprot/P37023#attribution-50A02E27588A8EB55C5A1C931EC9AB36 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/P55055#attribution-50A02E27588A8EB55C5A1C931EC9AB36 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z2Y4-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z310-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_B6ZGS7-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_B3KRG6-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_B4E0D4-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_B4DUF0-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_B4DPT9-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_G3V1W8-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |
| http://purl.uniprot.org/uniprot/#_D9IPD9-mappedCitation-12393874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393874 |