| http://purl.uniprot.org/citations/12398897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12398897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12398897 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-kappa B is a transcription factor that can protect from or contribute to apoptosis. Here we report identification of HSCO that binds to NF-kappa B and inhibits apoptosis. HSCO mRNA was overexpressed in 20 of 30 hepatocellular carcinomas analyzed. Overexpression of HSCO inhibited caspase 9 activation and apoptosis induced by DNA damaging agents, while it augmented apoptosis induced by TNFalpha. Like I kappa B alpha, HSCO inhibited NF-kappa B activity and abrogated p53-induced apoptosis. However, the underlying mechanism was different. HSCO is a nuclear-cytoplasmic shuttling protein, bound to RelA NF-kappa B, and HSCO sequestered it in the cytoplasm by accelerating its export from the nucleus. These results suggest that overexpression of HSCO suppresses p53-induced apoptosis by preventing nuclear localization of NF-kappa B during signaling and thus contributes to hepatocarcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1535-6108(02)00152-6"xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1535-6108(02)00152-6"xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Fujii S."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Fujii S."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Itoh K."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Itoh K."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Nagao T."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Nagao T."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Fujita J."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Fujita J."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Higashitsuji H."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Higashitsuji H."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Nonoguchi K."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Nonoguchi K."xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Higashitsuji H.'"xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/author | "Higashitsuji H.'"xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/pages | "335-346"xsd:string |
| http://purl.uniprot.org/citations/12398897 | http://purl.uniprot.org/core/pages | "335-346"xsd:string |