| http://purl.uniprot.org/citations/12408816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12408816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12408816 | http://www.w3.org/2000/01/rdf-schema#comment | "The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin-sensitive manner. TOR2 additionally regulates polarization of the actin cytoskeleton in a rapamycin-insensitive manner. We describe two functionally distinct TOR complexes. TOR Complex 1 (TORC1) contains TOR1 or TOR2, KOG1 (YHR186c), and LST8. TORC2 contains TOR2, AVO1 (YOL078w), AVO2 (YMR068w), AVO3 (YER093c), and LST8. FKBP-rapamycin binds TORC1, and TORC1 disruption mimics rapamycin treatment, suggesting that TORC1 mediates the rapamycin-sensitive, TOR-shared pathway. FKBP-rapamycin fails to bind TORC2, and TORC2 disruption causes an actin defect, suggesting that TORC2 mediates the rapamycin-insensitive, TOR2-unique pathway. Thus, the distinct TOR complexes account for the diversity, specificity, and selective rapamycin inhibition of TOR signaling. TORC1 and possibly TORC2 are conserved from yeast to man."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00636-6"xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00636-6"xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Jenoe P."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Jenoe P."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Jacinto E."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Jacinto E."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Crespo J.L."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Crespo J.L."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Bonenfant D."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Bonenfant D."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Hall M.N."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Hall M.N."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Loewith R."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Loewith R."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Lorberg A."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Lorberg A."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Oppliger W."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Oppliger W."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Wullschleger S."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/author | "Wullschleger S."xsd:string |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12408816 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |