| http://purl.uniprot.org/citations/12408964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12408964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12408964 | http://www.w3.org/2000/01/rdf-schema#comment | "Nesprin-1 and nesprin-2 (also known as Syne-1 and Syne-2,) are large ( approximately 3300-residue) vertebrate proteins associated with emerin and lamin A at the nuclear envelope of muscle cells and other cell types. We show that the previously described nesprins are short isoforms of giant proteins comprising an actin-binding amino-terminus connected to a carboxy-terminal klarsicht-related transmembrane domain by a massive ( approximately 6000-8000 amino acid) spectrin-like rod domain, making full-length nesprin-1, at one megadalton, the largest non-titin protein hitherto described in humans. We find that MSP-300, a 7000-residue Drosophila melanogaster protein whose disruption results in defects of muscle development, corresponds to the N-terminal two-thirds of the Drosophila nesprin ortholog. A nesprin-like protein is also encoded by the nematode genome. Moreover, we demonstrate that the larger isoforms of nesprin-1, like MSP-300, are localized to the sarcomeric Z-line of both skeletal and cardiac muscle. The recognition that a characteristic muscle-specific mutant phenotype in the fly results from a disruption of its nesprin ortholog reinforces the candidacy of the human proteins for involvement in genetic diseases of skeletal and cardiac muscle."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0888-7543(02)96859-x"xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0888-7543(02)96859-x"xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0888-7543(02)96859-X"xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Greener M.J."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Greener M.J."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Ragnauth C."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Ragnauth C."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Roberts R.G."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Roberts R.G."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Shanahan C.M."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/author | "Shanahan C.M."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/pages | "473-481"xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/pages | "473-481"xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/title | "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/title | "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."xsd:string |
| http://purl.uniprot.org/citations/12408964 | http://purl.uniprot.org/core/volume | "80"xsd:string |