| http://purl.uniprot.org/citations/12437926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12437926 | http://www.w3.org/2000/01/rdf-schema#comment | "We report here that PLC-gamma isoforms are required for agonist-induced Ca2+ entry (ACE). Overexpressed wild-type PLC-gamma1 or a lipase-inactive mutant PLC-gamma1 each augmented ACE in PC12 cells, while a deletion mutant lacking the region containing the SH3 domain of PLC-gamma1 was ineffective. RNA interference to deplete either PLC-gamma1 or PLC-gamma2 in PC12 and A7r5 cells inhibited ACE. In DT40 B lymphocytes expressing only PLC-gamma2, overexpressed muscarinic M5 receptors (M5R) activated ACE. Using DT40 PLC-gamma2 knockout cells, M5R stimulation of ER Ca2+ store release was unaffected, but ACE was abolished. Normal ACE was restored by transient expression of PLC-gamma2 or a lipase-inactive PLC-gamma2 mutant. The results indicate a lipase-independent role of PLC-gamma in the physiological agonist-induced activation of Ca2+ entry."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)01045-0"xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "Kurosaki T."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "Bae S.S."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "Snyder S.H."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "Hurt K.J."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "Suh P.G."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "Gill D.L."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "Patterson R.L."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "van Rossum D.B."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/author | "Ford D.L."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/pages | "529-541"xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/title | "Phospholipase C-gamma is required for agonist-induced Ca2+ entry."xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/12437926 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12437926 |
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