| http://purl.uniprot.org/citations/12445581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12445581 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to investigate in rat gastric fundus whether L-citrulline, the co-product in the nitric oxide (NO) biosynthesis catalyzed by neuronal nitric oxide synthase (nNOS), can be converted back to the nNOS substrate L-arginine. Immunohistochemistry showed that argininosuccinate synthetase and argininosuccinate lyase, that mediate transformation of L-citrulline to L-arginine in the ureum cycle in hepatocytes, co-localize with nNOS. In longitudinal smooth muscle strips, L-arginine as well as L-citrulline (10(-3) M) was capable of completely respectively partially preventing the N(G)-nitro-L-arginine methyl ester (L-NAME) (3 x 10(-5) M)-induced inhibition of electrically induced nitrergic relaxations, whereas D-citrulline (10(-3) M) was not. The L-citrulline-mediated prevention of the L-NAME-induced inhibition was reduced by L-glutamine (3 x 10(-3) M), the putative L-citrulline uptake inhibitor, and by succinate, an argininosuccinate lyase inhibitor. The results demonstrate that the L-citrulline recycling mechanism is active in rat gastric fundus. Recycling of L-citrulline might play a role in providing sufficient amounts of nNOS substrate during long-lasting relaxations in gastric fundus after food intake."xsd:string |
| http://purl.uniprot.org/citations/12445581 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-2999(02)02584-0"xsd:string |
| http://purl.uniprot.org/citations/12445581 | http://purl.uniprot.org/core/author | "Timmermans J.P."xsd:string |
| http://purl.uniprot.org/citations/12445581 | http://purl.uniprot.org/core/author | "Lefebvre R.A."xsd:string |
| http://purl.uniprot.org/citations/12445581 | http://purl.uniprot.org/core/author | "Van Geldre L.A."xsd:string |
| http://purl.uniprot.org/citations/12445581 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12445581 | http://purl.uniprot.org/core/name | "Eur J Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/12445581 | http://purl.uniprot.org/core/pages | "149-160"xsd:string |
| http://purl.uniprot.org/citations/12445581 | http://purl.uniprot.org/core/title | "L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus."xsd:string |
| http://purl.uniprot.org/citations/12445581 | http://purl.uniprot.org/core/volume | "455"xsd:string |
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