| http://purl.uniprot.org/citations/12447358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12447358 | http://www.w3.org/2000/01/rdf-schema#comment | "The ZAP-70 tyrosine kinase is a key component of the signaling machinery for the T cell antigen receptor (TCR). Whereas recruitment and activation of ZAP-70 are relatively well understood, the proteins phosphorylated by ZAP-70 are incompletely known. We report here that VHR, a Vaccinia virus VH1-related dual-specific protein phosphatase that inactivates the mitogen-activated kinases Erk2 and Jnk, is phosphorylated at Y138 by ZAP-70. Tyr138 phosphorylation was required for VHR to inhibit the Erk2-Elk-1 pathway and, conversely, the VHR(Y138F) mutant augmented TCR-induced Erk2 kinase and activation of the gene encoding interleukin 2. These results suggest that VHR is a target for ZAP-70 and tempers activation of the Erk2 pathway in a ZAP-70-controlled manner."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni856"xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "Godzik A."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "Jaroszewski L."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "Williams S."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "Alonso A."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "Abraham R.T."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "Mustelin T."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "Rahmouni S."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "Schoenberger S.P."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/author | "van Stipdonk M."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/pages | "44-48"xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/title | "Tyrosine phosphorylation of VHR phosphatase by ZAP-70."xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12447358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12447358 |
| http://purl.uniprot.org/citations/12447358 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12447358 |
| http://purl.uniprot.org/uniprot/P51452#attribution-E1532665BDD5C36F527142AABFC54A9C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12447358 |
| http://purl.uniprot.org/uniprot/P43403#attribution-E1532665BDD5C36F527142AABFC54A9C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12447358 |
| http://purl.uniprot.org/uniprot/#_B4E0E2-mappedCitation-12447358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12447358 |
| http://purl.uniprot.org/uniprot/#_B5BUI8-mappedCitation-12447358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12447358 |
| http://purl.uniprot.org/uniprot/#_P43403-mappedCitation-12447358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12447358 |
| http://purl.uniprot.org/uniprot/#_P51452-mappedCitation-12447358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12447358 |