| http://purl.uniprot.org/citations/12447383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12447383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12447383 | http://www.w3.org/2000/01/rdf-schema#comment | "The small GTPase Rab6a is involved in the regulation of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) in a coat complex coatomer protein I (COPI)-independent pathway. Here, we used a yeast two-hybrid approach to identify binding partners of Rab6a. In particular, we identified the dynein-dynactin-binding protein Bicaudal-D1 (BICD1), one of the two mammalian homologues of Drosophila Bicaudal-D. BICD1 and BICD2 colocalize with Rab6a on the trans-Golgi network (TGN) and on cytoplasmic vesicles, and associate with Golgi membranes in a Rab6-dependent manner. Overexpression of BICD1 enhances the recruitment of dynein-dynactin to Rab6a-containing vesicles. Conversely, overexpression of the carboxy-terminal domain of BICD, which can interact with Rab6a but not with cytoplasmic dynein, inhibits microtubule minus-end-directed movement of green fluorescent protein (GFP)-Rab6a vesicles and induces an accumulation of Rab6a and COPI-independent ER cargo in peripheral structures. These data suggest that coordinated action between Rab6a, BICD and the dynein-dynactin complex controls COPI-independent Golgi-ER transport."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb891"xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb891"xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Hoogenraad C.C."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Hoogenraad C.C."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Barnekow A."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Barnekow A."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Galjart N."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Galjart N."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Matanis T."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Matanis T."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Akhmanova A."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Akhmanova A."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Grosveld F."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Grosveld F."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Goud B."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Goud B."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "De Zeeuw C.I."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "De Zeeuw C.I."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Del Nery E."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Del Nery E."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Stepanova T."xsd:string |
| http://purl.uniprot.org/citations/12447383 | http://purl.uniprot.org/core/author | "Stepanova T."xsd:string |