| http://purl.uniprot.org/citations/12467573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12467573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12467573 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase domains for three cancer-associated protein kinases: ephrin receptor A2 (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors of these kinases may have inherent potential as therapeutic agents. The structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and the design of selective inhibitors."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0969-2126(02)00907-3"xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0969-2126(02)00907-3"xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Rogers J."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Rogers J."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Swanson R.V."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Swanson R.V."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Knuth M.W."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Knuth M.W."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Nowakowski J."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Nowakowski J."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Thompson D.A."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Thompson D.A."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Sang B.C."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Sang B.C."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "McRee D.E."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "McRee D.E."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Nelson C.G."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Nelson C.G."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Cronin C.N."xsd:string |
| http://purl.uniprot.org/citations/12467573 | http://purl.uniprot.org/core/author | "Cronin C.N."xsd:string |