| http://purl.uniprot.org/citations/12473693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12473693 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell migration involves many steps, including membrane protrusion and the development of new adhesions. Here we have investigated whether there is a link between actin polymerization and integrin engagement. In response to signals that trigger membrane protrusion, the actin-related protein (Arp)2/3 complex transiently binds to vinculin, an integrin-associated protein. The interaction is regulated, requiring phosphatidylinositol-4,5-bisphosphate and Rac1 activation, and is sufficient to recruit the Arp2/3 complex to new sites of integrin aggregation. Binding of the Arp2/3 complex to vinculin is direct and does not depend on the ability of vinculin to associate with actin. We have mapped the binding site for the Arp2/3 complex to the hinge region of vinculin, and a point mutation in this region selectively blocks binding to the Arp2/3 complex. Compared with WT vinculin, expression of this mutant in vinculin-null cells results in diminished lamellipodial protrusion and spreading on fibronectin. The recruitment of the Arp2/3 complex to vinculin may be one mechanism through which actin polymerization and membrane protrusion are coupled to integrin-mediated adhesion."xsd:string |
| http://purl.uniprot.org/citations/12473693 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200206043"xsd:string |
| http://purl.uniprot.org/citations/12473693 | http://purl.uniprot.org/core/author | "Burridge K."xsd:string |
| http://purl.uniprot.org/citations/12473693 | http://purl.uniprot.org/core/author | "DeMali K.A."xsd:string |
| http://purl.uniprot.org/citations/12473693 | http://purl.uniprot.org/core/author | "Barlow C.A."xsd:string |
| http://purl.uniprot.org/citations/12473693 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12473693 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12473693 | http://purl.uniprot.org/core/pages | "881-891"xsd:string |
| http://purl.uniprot.org/citations/12473693 | http://purl.uniprot.org/core/title | "Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion."xsd:string |
| http://purl.uniprot.org/citations/12473693 | http://purl.uniprot.org/core/volume | "159"xsd:string |
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