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http://purl.uniprot.org/citations/12476414http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12476414http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12476414http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Cloning and characterization of a novel gene by exon trapping and exon linking at chromosome 8p22.

Methods

A novel gene was cloned using exon trapping and exon linking, and its expression was determined by reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot.

Results

A sequence containing 3 exons was found. The sequence is homologous with the putative gene AK024799 which consists of 2880 bp cDNA with 1362 bp open reading frame and codes 454 amino acids with an SH(2) domain. The gene was named SH(2)A at chromosome 8p22. SH(2)A gene is ubiquitously expressed in various tissues with three transcripts. The aberrant expression of SH(2)A gene in some cancers was detected.

Conclusion

SH(2)A is a novel docking protein of SH(2) signaling protein family, which may play an important role in cellular signal transduction. It relates to the pathogenesis of tumor."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/author"Zhao Y."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/author"Zhao Y."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/author"Dai S."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/author"Dai S."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/author"Ding Q."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/author"Ding Q."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/pages"458-462"xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/pages"458-462"xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/title"A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/title"A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene."xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/12476414http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/12476414http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12476414
http://purl.uniprot.org/citations/12476414http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12476414
http://purl.uniprot.org/citations/12476414http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12476414
http://purl.uniprot.org/citations/12476414http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12476414
http://purl.uniprot.org/uniprot/Q9H788http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/12476414
http://purl.uniprot.org/embl-cds/AAO41715.1http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/12476414
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