| http://purl.uniprot.org/citations/12480931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12480931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12480931 | http://www.w3.org/2000/01/rdf-schema#comment | "The Alzheimer-linked neural protein S100B is a signaling molecule shown to control the assembly of intermediate filament proteins in a calcium-sensitive manner. Upon binding calcium, a conformational change occurs in S100B exposing a hydrophobic surface for target protein interactions. The synthetic peptide TRTK-12 (TRTKIDWNKILS), derived from random bacteriophage library screening, bears sequence similarity to several intermediate filament proteins and has the highest calcium-dependent affinity of any target molecule for S100B to date (K(d) <1 microm). In this work, the three-dimensional structure of the Ca(2+)-S100B-TRTK-12 complex has been determined by NMR spectroscopy. The structure reveals an extended, contiguous hydrophobic surface is formed on Ca(2+)-S100B for target interaction. The TRTK-12 peptide adopts a coiled structure that fits into a portion of this surface, anchored at Trp(7), and interacts with multiple hydrophobic contacts in helices III and IV of Ca(2+)-S100B. This interaction is strikingly different from the alpha-helical structures found for other S100 target peptides. By using the TRTK-12 interaction as a guide, in combination with other available S100 target structures, a recognition site on helix I is identified that may act in concert with the TRTK-12-binding site from helices III and IV. This would provide a larger, more complex site to interact with full-length target proteins and would account for the promiscuity observed for S100B target protein interactions."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210622200"xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210622200"xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/author | "Shaw G.S."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/author | "Shaw G.S."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/author | "McClintock K.A."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/author | "McClintock K.A."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/pages | "6251-6257"xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/pages | "6251-6257"xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/title | "A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/title | "A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex."xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12480931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12480931 |
| http://purl.uniprot.org/citations/12480931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12480931 |
| http://purl.uniprot.org/citations/12480931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12480931 |
| http://purl.uniprot.org/citations/12480931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12480931 |
| http://purl.uniprot.org/uniprot/P52907 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12480931 |
| http://purl.uniprot.org/uniprot/P04271 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12480931 |