| http://purl.uniprot.org/citations/12505986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12505986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12505986 | http://www.w3.org/2000/01/rdf-schema#comment | "Cargo transfer from trans-Golgi network (TGN)-derived transport carriers to endosomes involves a still undefined set of tethering/fusion events. Here we analyze a molecular interaction that may play a role in this process. We demonstrate that the GGAs, a family of Arf-dependent clathrin adaptors involved in selection of TGN cargo, interact with the Rabaptin-5-Rabex-5 complex, a Rab4/Rab5 effector regulating endosome fusion. These interactions are bipartite: GGA-GAE domains recognize an FGPLV sequence (residues 439-443) in a predicted random coil of Rabaptin-5 (a sequence also recognized by the gamma1- and gamma2-adaptin ears), while GGA-GAT domains bind to the C-terminal coiled-coils of Rabaptin-5. The GGA-Rabaptin-5 interaction decreases binding of clathrin to the GGA-hinge domain, and expression of green fluorescent protein (GFP)-Rabaptin-5 shifts the localization of endogenous GGA1 and associated cargo to enlarged early endosomes. These observations thus identify a binding sequence for GAE/gamma-adaptin ear domains and reveal a functional link between proteins regulating TGN cargo export and endosomal tethering/fusion events."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg015"xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg015"xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Lodge R."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Lodge R."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Bonifacino J.S."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Bonifacino J.S."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Mattera R."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Mattera R."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Arighi C.N."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/author | "Arighi C.N."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/pages | "78-88"xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/pages | "78-88"xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/title | "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/title | "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12505986 | http://purl.uniprot.org/core/volume | "22"xsd:string |