| http://purl.uniprot.org/citations/12511571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12511571 | http://www.w3.org/2000/01/rdf-schema#comment | "Heme oxygenase 1 (HO-1) catalyzes heme breakdown, eventually releasing iron, carbon monoxide, and bilirubin IXalpha. HO-1 is induced by its substrate heme and various environmental factors, which represents a protective response against oxidative stresses. Here we show that hypoxia represses HO-1 expression in three human cell types but induces it in rat, bovine, and monkey cells, indicating the inter-species difference in the hypoxic regulation of HO-1 expression. The hypoxia-mediated repression of HO-1 expression is consistently associated with the induction of Bach1, a heme-regulated transcriptional repressor, in human cells. Bach1 is a basic leucine zipper protein, forming a heterodimer with a small Maf protein. Expression of HO-1 was also reduced in human cells when exposed to interferon-gamma or an iron chelator desferrioxamine, each of which induced Bach1 expression. In contrast, induction of HO-1 expression by CoCl(2) is associated with reduced expression of Bach1 mRNA. Thus, expression of HO-1 and Bach1 is inversely regulated. We have identified a Maf recognition element in the human HO-1 gene that is required for repression of a reporter gene by hypoxia and targeted by Bach1. Therefore, Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m209939200"xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Igarashi K."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Fujita H."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Nakayama M."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Ogawa K."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Hattori T."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Shibahara S."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Shirato K."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Furuyama K."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Hida W."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Kitamuro T."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/author | "Udono-Fujimori R."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/pages | "9125-9133"xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/title | "Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells."xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12511571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12511571 |
| http://purl.uniprot.org/citations/12511571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12511571 |
| http://purl.uniprot.org/uniprot/O14867#attribution-AC2995D5650CECC8EEF6954653D302A6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12511571 |