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| http://purl.uniprot.org/citations/12526776 | http://www.w3.org/2000/01/rdf-schema#comment | "Sr(2+) triggers neurotransmitter release similar to Ca(2+), but less efficiently. We now show that in synaptotagmin 1 knockout mice, the fast component of both Ca(2+)- and Sr(2+)-induced release is selectively impaired, suggesting that both cations partly act by binding to synaptotagmin 1. Both the C(2)A and the C(2)B domain of synaptotagmin 1 bind Ca(2+) in phospholipid complexes, but only the C(2)B domain forms Sr(2+)/phospholipid complexes; therefore, Sr(2+) binding to the C(2)B domain is sufficient to trigger fast release, although with decreased efficacy. Ca(2+) induces binding of the synaptotagmin C(2) domains to SNARE proteins, whereas Sr(2+) even at high concentrations does not. Thus, triggering of the fast component of release by Sr(2+) as a Ca(2+) agonist involves the formation of synaptotagmin/phospholipid complexes, but does not require stimulated SNARE binding."xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)01145-5"xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/author | "Sugita S."xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/author | "Rhee J.S."xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/author | "Shin O.H."xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/pages | "99-108"xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/title | "Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions."xsd:string |
| http://purl.uniprot.org/citations/12526776 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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