| http://purl.uniprot.org/citations/12526811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12526811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12526811 | http://www.w3.org/2000/01/rdf-schema#comment | "The HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the trans-Golgi network (TGN) enables HIV-1 to escape immune surveillance. However, the cellular pathway used by Nef to downregulate MHC-I is unknown. Here, we show that Nef and PACS-1 combine to usurp the ARF6 endocytic pathway by a PI3K-dependent process and downregulate cell surface MHC-I to the TGN. This mechanism requires the hierarchical actions of three Nef motifs-the acidic cluster 62EEEE(65), the SH3 domain binding site 72PXXP(75), and M(20)-in controlling PACS-1-dependent sorting to the TGN, ARF6 activation, and sequestering internalized MHC-I to the TGN, respectively. These data provide new insights into the cellular basis of HIV-1 immunoevasion."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)01162-5"xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)01162-5"xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Thomas L."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Thomas L."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Hung C.-H."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Hung C.-H."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Blagoveshchenskaya A.D."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Blagoveshchenskaya A.D."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Feliciangeli S.F."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/author | "Feliciangeli S.F."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/pages | "853-866"xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/pages | "853-866"xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/title | "HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/title | "HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway."xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/12526811 | http://purl.uniprot.org/core/volume | "111"xsd:string |