| http://purl.uniprot.org/citations/12527764 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12527764 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12527764 | http://www.w3.org/2000/01/rdf-schema#comment | "The six minichromosome maintenance proteins (Mcm2-7) are required for both the initiation and elongation of chromosomal DNA, ensuring that DNA replication takes place once, and only once, during the S phase. Here we report on the cloning of a new human Mcm gene (hMcm8) and on characterisation of its protein product. The hMcm8 gene contains the central Mcm domain conserved in the Mcm2-7 gene family, and is expressed in a range of cell lines and human tissues. hMcm8 mRNA accumulates during G(1)/S phase, while hMcm8 protein is detectable throughout the cell cycle. Immunoprecipitation-based studies did not reveal any participation of hMcm8 in the Mcm3/5 and Mcm2/4/6/7 subcomplexes. hMcm8 localises to the nucleus, although it is devoid of a nuclear localisation signal, suggesting that it binds to a nuclear protein. In the nucleus, the hMcm8 structure-bound fraction is detectable in S, but not in G(2)/M, phase, as for hMcm3. However, unlike hMcm3, the hMcm8 structure-bound fraction is not detectable in G(1) phase. Overall, our data identify a new Mcm protein, which does not form part of the Mcm2-7 complex and which is only structure-bound during S phase, thus suggesting its specific role in DNA replication."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkg136"xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkg136"xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Chami M."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Chami M."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Poch O."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Poch O."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Knippers R."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Knippers R."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Brechot C."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Brechot C."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Gozuacik D."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Gozuacik D."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Paterlini-Brechot P."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Paterlini-Brechot P."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Biermann E."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Biermann E."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Faivre J."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Faivre J."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Lagorce D."xsd:string |
| http://purl.uniprot.org/citations/12527764 | http://purl.uniprot.org/core/author | "Lagorce D."xsd:string |