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| http://purl.uniprot.org/citations/12536214 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulated incorporation of AMPA receptors into synapses is important for synaptic plasticity. Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus. Activity-driven PKA phosphorylation of GluR4 was necessary and sufficient to relieve a retention interaction and drive receptors into synapses. In contrast, PKA phosphorylation of GluR1 and the activity of calcium/calmodulin-dependent kinase II (CaMKII) were both necessary for receptor incorporation. Thus, PKA phosphorylation of AMPA receptor subunits contributes to diverse mechanisms underlying synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn997"xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/author | "Esteban J.A."xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/author | "Wilson C."xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/author | "Huganir R.L."xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/author | "Shi S.H."xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/author | "Malinow R."xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/author | "Nuriya M."xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/pages | "136-143"xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/title | "PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity."xsd:string |
| http://purl.uniprot.org/citations/12536214 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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