| http://purl.uniprot.org/citations/12553878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12553878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12553878 | http://www.w3.org/2000/01/rdf-schema#comment | "Connective tissue growth factor (CTGF) is a 349-residue mosaic protein that contains four structural modules implicated in protein-protein interactions. To address the functionality of residues 247-349 (containing module 4 alone), this region of CTGF was produced as a maltose binding protein (MBP) fusion protein in E. coli. After removal of MBP, recombinant CTGF commenced at Glu(247), was of M(r) 10 000, was immunoreactive with anti-CTGF[247-260], bound strongly to heparin, and promoted dose-dependent adhesion of fibroblasts, myofibroblasts, endothelial cells, and epithelial cells. An 8 kDa presumptive C-terminally truncated form of CTGF commencing at Glu(247) also promoted cell adhesion. CTGF-mediated cell adhesion was abolished by heparin or EDTA. These data demonstrate the presence of heparin-binding and cell-adhesion motifs within the C-terminal 103 residues of CTGF and show that CTGF-mediated cell adhesion is heparin-and divalent cation-dependent. Thus, CTGF isoforms comprising essentially module 4 are intrinsically functional in the absence of the other constituent modules of CTGF."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.org/dc/terms/identifier | "doi:10.1677/joe.0.176r001"xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.org/dc/terms/identifier | "doi:10.1677/joe.0.176r001"xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/author | "Ball D.K."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/author | "Ball D.K."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/author | "Brigstock D.R."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/author | "Brigstock D.R."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/author | "Kemper S.A."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/author | "Kemper S.A."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/author | "Rachfal A.W."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/author | "Rachfal A.W."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/name | "J. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/name | "J. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/pages | "R1-R7"xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/pages | "R1-R7"xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/title | "The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/title | "The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/12553878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12553878 |
| http://purl.uniprot.org/citations/12553878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12553878 |