| http://purl.uniprot.org/citations/12574121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12574121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12574121 | http://www.w3.org/2000/01/rdf-schema#comment | "Eph tyrosine kinase receptors and their membrane-bound ligands, ephrins, are presumed to regulate cell-cell interactions. The major consequence of bidirectional activation of Eph receptors and ephrin ligands is cell repulsion. In this study, we discovered that Xenopus Dishevelled (Xdsh) forms a complex with Eph receptors and ephrin-B ligands and mediates the cell repulsion induced by Eph and ephrin. In vitro re-aggregation assays with Xenopus animal cap explants revealed that co-expression of a dominant-negative mutant of Xdsh affected the sorting of cells expressing EphB2 and those expressing ephrin-B1. Co-expression of Xdsh induced the activation of RhoA and Rho kinase in the EphB2-overexpressed cells and in the cells expressing EphB2-stimulated ephrin-B1. Therefore, Xdsh mediates both forward and reverse signaling of EphB2 and ephrin-B1, leading to the activation of RhoA and its effector protein Rho kinase. The inhibition of RhoA activity in animal caps significantly prevents the EphB2- and ephrin-B1-mediated cell sorting. We propose that Xdsh, which is expressed in various tissues, is involved in EphB and ephrin-B signaling related to regulation of cell repulsion via modification of RhoA activity."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg088"xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg088"xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/author | "Ota S."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/author | "Ota S."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/author | "Kamo T."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/author | "Kamo T."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/author | "Sugimura H."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/author | "Sugimura H."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/pages | "847-858"xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/pages | "847-858"xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/title | "Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/title | "Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion."xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12574121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12574121 |
| http://purl.uniprot.org/citations/12574121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12574121 |