| http://purl.uniprot.org/citations/12577056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12577056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12577056 | http://www.w3.org/2000/01/rdf-schema#comment | "No genetic defect is known to cause common variable immunodeficiency (CVID), a heterogeneous human disorder leading to adult-onset panhypogammaglobulinemia. In a search for CVID candidate proteins, we found four of 32 patients to lack ICOS, the "inducible costimulator" on activated T cells, due to an inherited homozygous deletion in the ICOS gene. T cells from these individuals were normal with regard to subset distribution, activation, cytokine production and proliferation. In contrast, naive, switched and memory B cells were reduced. The phenotype of human ICOS deficiency, which differs in key aspects from that of the ICOS-/-mouse, suggests a critical involvement of ICOS in T cell help for late B cell differentiation, class-switching and memory B cell generation."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni902"xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni902"xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Fischer B."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Fischer B."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Eibel H."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Eibel H."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Grimbacher B."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Grimbacher B."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Schaeffer A.A."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Schaeffer A.A."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Peter H.H."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Peter H.H."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Warnatz K."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Warnatz K."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Kroczek R.A."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Kroczek R.A."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Mages H.W."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Mages H.W."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Schlesier M."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Schlesier M."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Draeger R."xsd:string |
| http://purl.uniprot.org/citations/12577056 | http://purl.uniprot.org/core/author | "Draeger R."xsd:string |