| http://purl.uniprot.org/citations/12582157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12582157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12582157 | http://www.w3.org/2000/01/rdf-schema#comment | "Tapasin plays an important role in the quality control of major histocompatibility complex (MHC) class I assembly, but its precise function in this process remains controversial. Whether tapasin participates in the assembly of HLA-G has not been studied. HLA-G, an MHC class Ib molecule that binds a more restricted set of peptides than class Ia molecules, is a particularly interesting molecule, because during assembly, it recycles between the endoplasmic reticulum (ER) and the cis-Golgi until it is loaded with a high affinity peptide. We have taken advantage of this unusual trafficking property of HLA-G and its requirement for high affinity peptides to demonstrate that a critical function of tapasin is to transform class I molecules into a high affinity, peptide-receptive form. In the absence of tapasin, HLA-G molecules cannot bind high affinity peptides, and an abundant supply of peptides cannot overcome the tapasin requirement for high affinity peptide loading. The addition of tapasin renders HLA-G molecules capable of loading high affinity peptides and of transporting to the surface, suggesting that tapasin is a prerequisite for the binding of high-affinity ligands. Interestingly, the "tapasin-dependent" HLA-G molecules are not empty in the absence of tapasin but are in fact associated with suboptimal peptides and continue to recycle between the ER and the cis-Golgi. Together with the finding that empty HLA-G heterodimers are strictly retained in the ER and degraded, our data suggest that MHC class I molecules bind any available peptides to avoid ER-mediated degradation and that the peptides are in turn replaced by higher affinity peptides with the aid of tapasin."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m212882200"xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m212882200"xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/author | "Park B."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/author | "Park B."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/author | "Ahn K."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/author | "Ahn K."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/pages | "14337-14345"xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/pages | "14337-14345"xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/title | "An essential function of tapasin in quality control of HLA-G molecules."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/title | "An essential function of tapasin in quality control of HLA-G molecules."xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12582157 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12582157 |
| http://purl.uniprot.org/citations/12582157 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12582157 |
| http://purl.uniprot.org/citations/12582157 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12582157 |
| http://purl.uniprot.org/citations/12582157 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12582157 |
| http://purl.uniprot.org/uniprot/P53618 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12582157 |
| http://purl.uniprot.org/uniprot/O15533 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12582157 |