| http://purl.uniprot.org/citations/12598895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12598895 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-specific immune responses. Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo. Id2-/-mice lack Langerhans cells (LCs), the cutaneous contingent of DCs, and the splenic CD8alpha+ DC subset is markedly reduced. Mice deficient for transforming growth factor (TGF)-beta also lack LCs, and we demonstrate here that, in DCs, TGF-beta induces Id2 expression. We also show that Id2 represses B cell genes in DCs. These findings reveal a TGF-beta-Id2 signaling pathway in DCs and suggest a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni903"xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Yokota Y."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Hacker C."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Zenke M."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Kuhl C."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Kurz S.M."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Gust T.C."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Hieronymus T."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Jorgas T."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Ju X.S."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/author | "Kirsch R.D."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/pages | "380-386"xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/title | "Transcriptional profiling identifies Id2 function in dendritic cell development."xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12598895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12598895 |
| http://purl.uniprot.org/citations/12598895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12598895 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VMT3-mappedCitation-12598895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12598895 |
| http://purl.uniprot.org/uniprot/#_Q53H99-mappedCitation-12598895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12598895 |
| http://purl.uniprot.org/uniprot/#_P41136-mappedCitation-12598895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12598895 |
| http://purl.uniprot.org/uniprot/#_Q53T66-mappedCitation-12598895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12598895 |