| http://purl.uniprot.org/citations/12646216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646216 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitin-protein ligases (E3s) determine the substrate specificity of ubiquitylation and, until recently, had been classified into two families, the HECT and RING-finger families. The U-box is a domain of approximately 70 amino acids that is present in proteins from yeast to humans. The prototype U-box protein, yeast Ufd2, was identified as a ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and an E3 to catalyze the formation of a ubiquitin chain on artificial substrates. We recently showed that mammalian U-box proteins, in conjunction with an E1 and an E2, mediate polyubiquitylation in the absence of a HECT type or RING-finger type E3. U-box proteins have thus been defined as a third family of E3s. We here review recent progress in the characterization of U-box proteins and of their role in the quality control system that underlies the cellular stress response to the intracellular accumulation of abnormal proteins."xsd:string |
| http://purl.uniprot.org/citations/12646216 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00245-6"xsd:string |
| http://purl.uniprot.org/citations/12646216 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/12646216 | http://purl.uniprot.org/core/author | "Nakayama K.I."xsd:string |
| http://purl.uniprot.org/citations/12646216 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12646216 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12646216 | http://purl.uniprot.org/core/pages | "635-645"xsd:string |
| http://purl.uniprot.org/citations/12646216 | http://purl.uniprot.org/core/title | "U-box proteins as a new family of ubiquitin ligases."xsd:string |
| http://purl.uniprot.org/citations/12646216 | http://purl.uniprot.org/core/volume | "302"xsd:string |
| http://purl.uniprot.org/citations/12646216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12646216 |
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| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-12646216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12646216 |
| http://purl.uniprot.org/uniprot/#_P51965-mappedCitation-12646216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12646216 |
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| http://purl.uniprot.org/uniprot/#_Q13191-mappedCitation-12646216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12646216 |