| http://purl.uniprot.org/citations/12651893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12651893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12651893 | http://www.w3.org/2000/01/rdf-schema#comment | "The positive transcription elongation factor b (P-TEFb) contains cyclin T1 (CycT1) and cyclin-dependent kinase 9 (Cdk9). For activating the expression of eukaryotic genes, the histidine-rich sequence in CycT1 binds the heptapeptide repeats in the C-terminal domain (CTD) of RNA polymerase II (RNAPII), whereupon Cdk9 phosphorylates the CTD. We found that alanine-substituted heptapeptide repeats that cannot be phosphorylated also bind CycT1. When placed near transcription units, these CTD analogs block effects of P-TEFb. Remarkably, the transcriptional repressor PIE-1 from Caenorhabditis elegans behaves analogously. It binds CycT1 via an alanine-containing heptapeptide repeat and inhibits transcriptional elongation. Thus, our findings reveal a new mechanism by which repressors inhibit eukaryotic transcription."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1068203"xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1068203"xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/author | "Peterlin B.M."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/author | "Peterlin B.M."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/author | "Blackwell T.K."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/author | "Blackwell T.K."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/author | "Barboric M."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/author | "Barboric M."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/pages | "748-758"xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/pages | "748-758"xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/title | "A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/title | "A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb."xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12651893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12651893 |
| http://purl.uniprot.org/citations/12651893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12651893 |