| http://purl.uniprot.org/citations/12654251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12654251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12654251 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Abl is normally regulated by an autoinhibitory mechanism, the disruption of which leads to chronic myelogenous leukemia. The details of this mechanism have been elusive because c-Abl lacks a phosphotyrosine residue that triggers the assembly of the autoinhibited form of the closely related Src kinases by internally engaging the SH2 domain. Crystal structures of c-Abl show that the N-terminal myristoyl modification of c-Abl 1b binds to the kinase domain and induces conformational changes that allow the SH2 and SH3 domains to dock onto it. Autoinhibited c-Abl forms an assembly that is strikingly similar to that of inactive Src kinases but with specific differences that explain the differential ability of the drug STI-571/Gleevec/imatinib (STI-571) to inhibit the catalytic activity of Abl, but not that of c-Src."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00194-6"xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00194-6"xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Kuriyan J."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Kuriyan J."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Scheffzek K."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Scheffzek K."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Nagar B."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Nagar B."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Bornmann W."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Bornmann W."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Clarkson B."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Clarkson B."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Hantschel O."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Hantschel O."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Veach D."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Veach D."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Young M.A."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/author | "Young M.A."xsd:string |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12654251 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |