| http://purl.uniprot.org/citations/12661006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12661006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12661006 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmembrane proto-oncogene receptor tyrosine kinase (RTK) ROS is an orphan receptor that is aberrantly expressed in neoplasms of the central nervous system. Here, we report the fusion of its carboxy-terminal kinase domain to the amino-terminal portion of a protein called FIG (Fused in Glioblastoma) in a human glioblastoma multiforme (GBM). By characterizing both FIG and ROS genes in normal and in U118MG GBM cells, we determined that an intra-chromosomal homozygous deletion of 240 kilobases on 6q21 is responsible for the formation of the FIG-ROS locus. The FIG-ROS transcript is encoded by 7 FIG exons and 9 ROS-derived exons. We also demonstrate that the FIG-ROS locus encodes for an in-frame fusion protein with a constitutively active kinase activity, suggesting that FIG-ROS may act as an oncogene. This is the first example of a fusion RTK protein that results from an intra-chromosomal deletion, and it represents the first fusion RTK protein isolated from a human astrocytoma."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.org/dc/terms/identifier | "doi:10.1002/gcc.10207"xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.org/dc/terms/identifier | "doi:10.1002/gcc.10207"xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Charest A."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Charest A."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Lane K."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Lane K."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Housman D."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Housman D."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Conroy H."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Conroy H."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "McMahon K."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "McMahon K."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Preisinger E."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/author | "Preisinger E."xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/name | "Genes Chromosomes Cancer"xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/name | "Genes Chromosomes Cancer"xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/pages | "58-71"xsd:string |
| http://purl.uniprot.org/citations/12661006 | http://purl.uniprot.org/core/pages | "58-71"xsd:string |