| http://purl.uniprot.org/citations/12679038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12679038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12679038 | http://www.w3.org/2000/01/rdf-schema#comment | "Entry into mitosis requires the activation of cdk1/cyclin B, while mitotic exit is achieved when the same kinase activity decreases, as cyclin B is degraded. Cyclin B proteolysis is mediated by the anaphase promoting complex, or APC, an E3 ligase that is active at anaphase in mitosis through G1. We have identified a G1 substrate of the APC that we have termed Tome-1, for trigger of mitotic entry. Tome-1 is a cytosolic protein required for proper activation of cdk1/cyclin B and mitotic entry. Tome-1 associates with Skp-1 and is required for degradation of the cdk1 inhibitory tyrosine kinase wee1; Tome-1 therefore appears to be acting as part of an SCF-type E3 for wee1. Degradation of Tome-1 during G1 allows for wee 1 accumulation during interphase, thereby providing a critical link between the APC and SCF pathways in regulation of cdk1/cyclin B activity and thus mitotic entry and exit."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00232-0"xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00232-0"xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Ayad N.G."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Ayad N.G."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Rankin S."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Rankin S."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Jebanathirajah J."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/author | "Jebanathirajah J."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/pages | "101-113"xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/pages | "101-113"xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/title | "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC."xsd:string |
| http://purl.uniprot.org/citations/12679038 | http://purl.uniprot.org/core/title | "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC."xsd:string |