| http://purl.uniprot.org/citations/12694406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12694406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12694406 | http://www.w3.org/2000/01/rdf-schema#comment | "APP-BP1, first identified as a protein that interacts with the carboxyl (C) terminus of the amyloid precursor protein (APP), is one-half of the bipartite activating enzyme for the ubiquitin-like protein NEDD8. We report here that APP-BP1 also specifically interacts with apoptosis stimulating protein of p53 ASPP2 in non-transfected cells through the functional predominant N-terminal domain ASPP2(332-483). ASPP2 inhibits the ability of APP-BP1 to rescue the ts41 cell cycle mutation and inhibits APP-BP1 induced apoptosis in primary neurons. ASPP2 reduces the ability of NEDD8 to conjugate to Cullin-1, inhibits APP-BP1-dependent ts41 cell proliferation, and blocks the ability of APP-BP1 to cause apoptosis and to cause DNA synthesis in neurons. We also show that ASPP2 activates nuclear factor-kappaB (NF-kappaB) transcriptional activity, which seems to be inhibited by the neddylation pathway since the dominant negative NEDD8 activating enzyme causes enhanced NF-kappaB activity. Our data provide the first in vivo evidence that ASPP2 is a negative regulator of the neddylation pathway through specific interaction with APP-BP1 and suggest that dysfunction of the APP-BP1 interaction with APP may be one cause of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2003.01727.x"xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2003.01727.x"xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/author | "Naumovski L."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/author | "Naumovski L."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/pages | "801-809"xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/pages | "801-809"xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/title | "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/title | "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/12694406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12694406 |
| http://purl.uniprot.org/citations/12694406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12694406 |