| http://purl.uniprot.org/citations/12700342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12700342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12700342 | http://www.w3.org/2000/01/rdf-schema#comment | "Certain triglyceride-rich lipoproteins (TRLs), specifically chylomicrons, dyslipemic VLDLs, and their remnants, are atherogenic and can induce monocyte-macrophage foam cell formation in vitro via the apolipoprotein B-48 receptor (apoB-48R). Human atherosclerotic lesion foam cells express the apoB-48R, as determined immunohistochemically, suggesting it can play a role in the conversion of macrophages into foam cells in vivo. The regulation of the apoB-48R in monocyte-macrophages is not fully understood, albeit previous studies indicated that cellular sterol levels and state of differentiation do not affect apoB-48R expression. Since peroxisome proliferator-activated receptors (PPARs) regulate some aspects of cellular lipid metabolism and may be protective in atherogenesis by up-regulation of liver X-activated receptor alpha and ATP-binding cassette transporter A1, we examined the regulation of apoB-48R by PPAR ligands in human monocyte-macrophages. Using real-time PCR, Northern, Western, and functional cellular lipid accumulation assays, we show that PPARalpha and PPARgamma activators significantly suppress the expression of apoB-48R mRNA in human THP-1 and blood-borne monocyte-macrophages. Moreover, PPAR activators inhibit the expression of the apoB-48R protein and, notably, the apoB-48R-mediated lipid accumulation of TRL by THP-1 monocytes in vitro. If PPAR activators also suppress the apoB-48R pathway in vivo, diminished apoB-48R-mediated monocyte-macrophage lipid accumulation may be yet another antiatherogenic effect of the action of PPAR ligands."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m300077-jlr200"xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m300077-jlr200"xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Tanaka A."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Tanaka A."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Bradley W.A."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Bradley W.A."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Brown M.L."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Brown M.L."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Gianturco S.H."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Gianturco S.H."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Haraguchi G."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Haraguchi G."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Isobe M."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/author | "Isobe M."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/name | "J. Lipid Res."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/name | "J. Lipid Res."xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/pages | "1224-1231"xsd:string |
| http://purl.uniprot.org/citations/12700342 | http://purl.uniprot.org/core/pages | "1224-1231"xsd:string |