| http://purl.uniprot.org/citations/12702807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12702807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12702807 | http://www.w3.org/2000/01/rdf-schema#comment | "Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the HCV NS3/4A serine protease blocks the phosphorylation and effector action of interferon regulatory factor-3 (IRF-3), a key cellular antiviral signaling molecule. Disruption of NS3/4A protease function by mutation or a ketoamide peptidomimetic inhibitor relieved this blockade and restored IRF-3 phosphorylation after cellular challenge with an unrelated virus. Furthermore, dominant-negative or constitutively active IRF-3 mutants, respectively, enhanced or suppressed HCV RNA replication in hepatoma cells. Thus, the NS3/4A protease represents a dual therapeutic target, the inhibition of which may both block viral replication and restore IRF-3 control of HCV infection."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1082604"xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1082604"xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Ikeda M."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Ikeda M."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Gale M. Jr."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Gale M. Jr."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Lemon S.M."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Lemon S.M."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Foy E."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Foy E."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Sumpter R. Jr."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/author | "Sumpter R. Jr."xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/pages | "1145-1148"xsd:string |
| http://purl.uniprot.org/citations/12702807 | http://purl.uniprot.org/core/pages | "1145-1148"xsd:string |