| http://purl.uniprot.org/citations/12727877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12727877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12727877 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite its implication in the progression of hepatitis B virus (HBV)-associated liver disease, the pro-apoptotic function of HBx protein remains poorly understood. We show that the expression of HBx leads to hyperactivation of caspase-8 and caspase-3 upon treatment with tumor necrosis factor-alpha (TNF-alpha) or anti-Fas antibody, and this activation is correlated with the sensitivity to apoptosis. We demonstrate cytoplasmic co-localization and direct interaction between HBx and the cellular FLICE inhibitory protein (c-FLIP), a key regulator of the death-inducing signaling complex (DISC). Deletion analysis shows that the death effector domain 1 (DED1) of c-FLIP is important for the observed interaction. Overexpression of c-FLIP rescued the cells from HBx-mediated apoptosis, with both the full-length HBV genome and HBx expression vectors. Moreover, c-FLIP and caspase-8 inhibitor considerably protected cells from HBx-mediated apoptosis. These data suggest that HBx abrogates the apoptosis-inhibitory function of c-FLIP and renders the cell hypersensitive towards the TNF-alpha apoptotic signal even below threshold concentration. This provides a novel mechanism for deregulation of hepatic cell growth in HBV patients and a new target for intervention in HBV-associated liver cancer and disease."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg210"xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg210"xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/author | "Seong B.L."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/author | "Seong B.L."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/pages | "2104-2116"xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/pages | "2104-2116"xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/title | "Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/title | "Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal."xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12727877 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12727877 |
| http://purl.uniprot.org/citations/12727877 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12727877 |
| http://purl.uniprot.org/citations/12727877 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12727877 |
| http://purl.uniprot.org/citations/12727877 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12727877 |
| http://purl.uniprot.org/uniprot/P0C686 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12727877 |
| http://purl.uniprot.org/uniprot/O15519 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12727877 |