| http://purl.uniprot.org/citations/12740378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12740378 | http://www.w3.org/2000/01/rdf-schema#comment | "In the central nervous system, excitatory synaptic transmission is mediated by the neurotransmitter glutamate and its receptors. Interestingly, stimulation of group I metabotropic glutamate receptors (mGluRs) can either enhance or depress synaptic transmission at CA1 hippocampal synapses. Here we report that co-activation of mGluR5, a member of the group I mGluR family, and N-methyl-d-aspartate receptors (NMDARs) potentiates NMDAR currents and induces a long lasting enhancement of excitatory synaptic transmission in primary cultured hippocampal neurons. Unexpectedly, activation of mGluR5 alone fails to enhance evoked NMDAR currents and synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) AMPAR currents. The observed potentiation requires an mGluR5-induced, inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular Ca2+, which acts in concert with a protein kinase C, calcium-activated tyrosine kinase cascade to induce a long lasting enhancement of NMDAR and AMPAR currents."xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m301946200"xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/author | "MacDonald J.F."xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/author | "Roder J.C."xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/author | "Jackson M.F."xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/author | "Kotecha S.A."xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/author | "Orser B.A."xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/author | "Al-Mahrouki A."xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/pages | "27742-27749"xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/title | "Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12740378 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12740378 |
| http://purl.uniprot.org/citations/12740378 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12740378 |
| http://purl.uniprot.org/uniprot/P31424#attribution-D105CB0629ED8C6A86A841C8F3DA1B3C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12740378 |
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| http://purl.uniprot.org/uniprot/#_P31424-mappedCitation-12740378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12740378 |
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| http://purl.uniprot.org/uniprot/P31424 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12740378 |
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