| http://purl.uniprot.org/citations/12780348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12780348 | http://www.w3.org/2000/01/rdf-schema#comment | "XB51 (derived from X11-like binding protein of clone number 51) was isolated by yeast two-hybrid cDNA screening using the N-terminal domain of X11L (X11-like protein) as a bait. X11L is a neuron-specific adaptor protein that is known to down-regulate APP (beta-amyloid precursor protein) metabolism by associating with the cytoplasmic domain of APP, but the detailed mechanisms are still unknown. Thus the X11L-associated protein XB51 is believed to regulate APP metabolism by modifying X11L function through its interaction with X11L. Here we report that the hXB51 (human XB51 ) gene can yield two transcripts, one with exon 9 spliced out (resulting in the hXB51beta isoform) and the other containing exon 9 (yielding the hXB51alpha isoform). hXB51alpha binds to X11L to form a tripartite complex composed of hXB51alpha, X11L and APP. Complex-formation results in blocking X11L's suppression of Abeta (beta-amyloid) generation from APP. hXB51beta associates with X11L and inhibits its interaction with APP. However, hXB51beta suppresses Abeta generation and secretion in an X11L-independent manner. Thus the hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner. These observations advance our understanding of the molecular mechanisms regulating intracellular Abeta production and the pathogenesis of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20030489"xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/author | "Kirino Y."xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/author | "Martins R.N."xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/author | "Imoto S."xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/author | "Sumioka A."xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/pages | "261-268"xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/title | "XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/12780348 | http://purl.uniprot.org/core/volume | "374"xsd:string |
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