| http://purl.uniprot.org/citations/12781872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12781872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12781872 | http://www.w3.org/2000/01/rdf-schema#comment | "Two alternative splice variants of the interleukin-1 receptor accessory protein (IL-1RAcP) mRNA are known. Membrane-bound IL-1RAcP (mIL-1RAcP) promotes intracellular interleukin-1 (IL-1) signalling whereas soluble IL-1RAcP (sIL-1RAcP) is probably an inhibitor of IL-1 signalling. Here we establish that sIL-1RAcP mRNA levels increase 16-fold in response to phorbol esters in the human hepatoma cell line HepG2 via a mechanism that depends on de novo protein synthesis. Following exposure of cells to UV light, a potent inducer of apoptosis, mIL-1RAcP mRNA is rapidly down-regulated and a new steady-state level established briefly before a gradual return to pretreatment levels. Following treatment with staurosporine, also an inducer of apoptosis, mIL-1RAcP mRNA levels steadily decrease through 72 h, with little change in sIL-1RAcP mRNA levels. A novel alternative splice variant, sIL-1RAcP-beta, was identified. Its sequence indicates that sIL-1RAcP-beta is secreted and has a unique second half of the third immunoglobulin (Ig) domain. The dramatic changes in levels of IL-1RAcP mRNAs suggest important functions in regulating sensitivity to IL-1 during stress and may play a role in oncogenic processes that are engaged during chronic inflammation."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0898-6568(03)00039-1"xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0898-6568(03)00039-1"xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/author | "Whitehead A.S."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/author | "Whitehead A.S."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/author | "Jensen L.E."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/author | "Jensen L.E."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/name | "Cell. Signal."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/name | "Cell. Signal."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/pages | "793-802"xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/pages | "793-802"xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/title | "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/title | "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/12781872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12781872 |
| http://purl.uniprot.org/citations/12781872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12781872 |
| http://purl.uniprot.org/citations/12781872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12781872 |
| http://purl.uniprot.org/citations/12781872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12781872 |
| http://purl.uniprot.org/uniprot/Q9NPH3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12781872 |
| http://purl.uniprot.org/uniprot/#_kb.Q9NPH3_up.isolatedFrom_tissue.564 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12781872 |