| http://purl.uniprot.org/citations/12789342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12789342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12789342 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokine-induced activation of the IkappaB kinases (IKK) IKK-alpha and IKK-beta is a key step involved in the activation of the NF-kappaB pathway. Gene-disruption studies of the murine IKK genes have shown that IKK-beta, but not IKK-alpha, is critical for cytokine-induced IkappaB degradation. Nevertheless, mouse embryo fibroblasts deficient in IKK-alpha are defective in the induction of NF-kappaB-dependent transcription. These observations raised the question of whether IKK-alpha might regulate a previously undescribed step to activate the NF-kappaB pathway that is independent of its previously described cytoplasmic role in the phosphorylation of IkappaBalpha. Here we show that IKK-alpha functions in the nucleus to activate the expression of NF-kappaB-responsive genes after stimulation with cytokines. IKK-alpha interacts with CREB-binding protein and in conjunction with Rel A is recruited to NF-kappaB-responsive promoters and mediates the cytokine-induced phosphorylation and subsequent acetylation of specific residues in histone H3. These results define a new nuclear role of IKK-alpha in modifying histone function that is critical for the activation of NF-kappaB-directed gene expression."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01576"xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01576"xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Yamamoto Y."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Yamamoto Y."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Gaynor R.B."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Gaynor R.B."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Kwak Y.T."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Kwak Y.T."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Prajapati S."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Prajapati S."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Verma U.N."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/author | "Verma U.N."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/pages | "655-659"xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/pages | "655-659"xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/title | "Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/title | "Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression."xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/volume | "423"xsd:string |
| http://purl.uniprot.org/citations/12789342 | http://purl.uniprot.org/core/volume | "423"xsd:string |