| http://purl.uniprot.org/citations/12796775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12796775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12796775 | http://www.w3.org/2000/01/rdf-schema#comment | "The anti-influenza CD8+ T cell response in HLA-A2-positive adults is almost exclusively directed at residues 58-66 of the virus matrix protein (MP(58-66)). V(beta)17V(alpha)10.2 T cell receptors (TCRs) containing a conserved arginine-serine-serine sequence in complementarity determining region 3 (CDR3) of the V(beta) segment dominate this response. To investigate the molecular basis of immunodominant selection in an outbred population, we have determined the crystal structure of V(beta)17V(alpha)10.2 in complex with MP(58-66)-HLA-A2 at a resolution of 1.4 A. We show that, whereas the TCR typically fits over an exposed side chain of the peptide, in this structure MP(58-66) exposes only main chain atoms. This distinctive orientation of V(beta)17V(alpha)10.2, which is almost orthogonal to the peptide-binding groove of HLA-A2, facilitates insertion of the conserved arginine in V(beta) CDR3 into a notch in the surface of MP(58-66)-HLA-A2. This previously unknown binding mode underlies the immunodominant T cell response."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni942"xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni942"xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "Bell J.I."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "Bell J.I."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "Stewart-Jones G.B.E."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/author | "Stewart-Jones G.B.E."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/pages | "657-663"xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/pages | "657-663"xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/title | "A structural basis for immunodominant human T cell receptor recognition."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/title | "A structural basis for immunodominant human T cell receptor recognition."xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12796775 | http://purl.uniprot.org/core/volume | "4"xsd:string |