| http://purl.uniprot.org/citations/12826668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12826668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12826668 | http://www.w3.org/2000/01/rdf-schema#comment | "Disabled (Dab) 1 and 2 are mammalian homologues of Drosophila DAB. Dab1 is a key cytoplasmic mediator in Reelin signaling that controls cell positioning in the developing central nervous system, whereas Dab2 is an adapter protein that plays a role in endocytosis. DAB family proteins possess an amino-terminal DAB homology (DH) domain that is similar to the phosphotyrosine binding/phosphotyrosine interaction (PTB/PI) domain. We have solved the structures of the DH domains of Dab2 (Dab2-DH) and Dab1 (Dab1-DH) in three different ligand forms, ligand-free Dab2-DH, the binary complex of Dab2-DH with the Asn-Pro-X-Tyr (NPXY) peptide of amyloid precursor protein (APP), and the ternary complex of Dab1-DH with the APP peptide and inositol 1,4,5-trisphosphate (Ins-1,4,5-P3, the head group of phosphatidylinositol-4,5-diphosphate (PtdIns-4,5-P2)). The similarity of these structures suggests that the rigid Dab DH domain maintains two independent pockets for binding of the APP/lipoprotein receptors and phosphoinositides. Mutagenesis confirmed the structural determinants specific for the NPXY sequence and PtdIns-4,5-P2 binding. NMR spectroscopy confirmed that the DH domain binds to Ins-1,4,5-P3 independent of the NPXY peptides. These findings suggest that simultaneous interaction of the rigid DH domain with the NPXY sequence and PtdIns-4,5-P2 plays a role in the attachment of Dab proteins to the APP/lipoprotein receptors and phosphoinositide-rich membranes."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m304384200"xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m304384200"xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Rock C.O."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Rock C.O."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Curran T."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Curran T."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Park H.W."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Park H.W."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Zhang Y.M."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Zhang Y.M."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Dickerson J.B."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Dickerson J.B."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Keshvara L."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Keshvara L."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Park C.G."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Park C.G."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Yun M."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/author | "Yun M."xsd:string |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12826668 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |