| http://purl.uniprot.org/citations/12840033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12840033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12840033 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA replication initiation is tightly controlled so that each origin only fires once per cell cycle. Cell cycle-dependent Cdt1 degradation plays an essential role in DNA replication control, as overexpression of Cdt1 leads to re-replication. In this study, we investigated the mechanisms of Cdt1 degradation in mammalian cells. We showed that the F-box protein Skp2 specifically interacted with human Cdt1 in a phosphorylation-dependent manner. The SCF(Skp2) complex ubiquitinated Cdt1 both in vivo and in vitro. Down-regulation of Skp2 or disruption of the interaction between Cdt1 and Skp2 resulted in a stabilization and accumulation of Cdt1. These results suggest that the SCF(Skp2)-mediated ubiquitination pathway may play an important role in the cell cycle-dependent Cdt1 degradation in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c300251200"xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c300251200"xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Liao R."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Liao R."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Sun P."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/author | "Sun P."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/pages | "30854-30858"xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/pages | "30854-30858"xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/title | "The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/title | "The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation."xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12840033 | http://purl.uniprot.org/core/volume | "278"xsd:string |